Mesenchymal Stem Cells
What is it?
Mesenchymal Stem cells(MSCs) are adult stem cells traditionally found in the bone marrow. They are multipotent stromal cells that can differentiate into many, if not all, varieties of cells: osteoblasts(bone cells), chondrocytes(cartilage cells), myocytes(muscle cells), cardiomyocytes(heart cells) and adipocytes(fat cells) included.
Morphologically, mesenchymal stem cells have long thin cell bodies with a large nucleus. As with other stem cell types, MSCs have a high capacity for self renewal while maintaining multipotency. Thus, mesenchymal stem cells have enormous therapeutic potential for tissue repair in dentistry
BioXclude MSCs study:
In one study, by Koob Et Al, human bone marrow MSCs were seeded onto the filter in a transwell culture model with samples of dehydrated amnion chorion (noted in the study as dHACM) placed below. At 24 hours, the soluble growth factors from the tissue samples drew MSCs toward the amnion chorion allograft. At 7 days, statistically significant higher cell counts of migrating MSCs were observed with the amnion chorion samples relative to the controls. Currently available off-the-shelf recombinant growth factors products have the ability to influence stem cells. This research supports that BioXclude also possess this attribute, and reiterates why it should be viewed not only as a barrier membrane, but also as a growth factor.